Rockland/ACVR1C Antibody/600401X68/100 µg

ACVR1CAntibodyProperties

Description

Anti-ACVR1C(RABBIT)Antibody-600-401-X68

Host

Rabbit

TargetSpecies

Human

KnownCrossReactivity

Human,mouse,rat

Clonality

Polyclonal

Application

ELISA:1:10,000-1:20,000
WesternBlot:1-2µg/mL

PhysicalState

Liquid(sterilefiltered)

ShippingCondition

DryIce

Format

IgG

Label

Unconjugated

Concentration

1mg/mLbyUVabsorbanceat280nm

Buffer

0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2

Preservative

0.02%(w/v)SodiumAzide

Stabilizer

None

GeneName

ACVR1

RelevantLinks

UniProtKB-Q04771
GeneID-90
NCBI-NP_001096

ACVR1CAntibodyDescription

Background

Activinsaredimericgrowthanddifferentiationfactorswhichbelongtothetransforminggrowthfactor-beta(TGF-beta)superfamilyofstructurallyrelatedsignalingproteins.ActivinssignalthroughaheteromericcomplexofreceptorserinekinaseswhichincludeatleasttwotypeIandtwotypeIIreceptors.ACVR1C,alsoknownasALK7,isatypeIactivinreceptorandplaysaroleincelldifferentiation,growtharrestandapoptosis.ACVR1CcanmediatesignalingbyliganssuchasNodal,GDF-1/3,activinBandactivinAB,allofwhichcanalsosignalthroughtheubiquitousactivintypeIreceptorACVR1B(alsoknownasALK4).ACVR1CisanovelMarkerspecificallyexpressedduringthelatephaseofadipocytedifferentiation.ACVR1Cisdispensableformouseembryogenesis,whichsuggestsalternativefunctionsforthisreceptorinpostnataldevelopmentandtissuehomeostasis.ACVR1Cplaysanimportantroleinregulatingthefunctionalplasticityofpancreaticislets,negativelyaffectingbeta-cellfunctionbymediatingtheeffectsofactivinBonCa2+signaling.

Synonyms

ACVR1CAntibody,FOP,ALK2,SKR1,TSRI,ACTRI,ACVR1A,ACVRLK2,Activinreceptortype-1,ActivinreceptortypeI,ACTR-I

Immunogen

Anti-ACVR1Cantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswitha15aminoacidsyntheticpeptideneartheN-terminusofthehumanACVR1C.

ImmunogenType

Peptide

StorageCondition

Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.

ApplicationNote

Anti-ACVR1CAntibodyhasbeentestedforuseinELISAandWesternBlotting.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandat~57kDainsizecorrespondingtothemolecularweightoftheACVR1CproteinbyWesternBlottingintheappropriatecelllysateorextract.

Purity/Specifity

Anti-ACVR1CAntibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.Thisantibodyispredictedtohavenocross-reactivitytoACVR1orACVR1B.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.Theprospectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

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Rockland/ACVR1C Antibody/600401X68/100 µg

ACVR1CAntibodyProperties

ACVR1CAntibodyDescription