Rockland/ARHGAP22 phospho S22 Antibody/600401J11/50 µg

ARHGAP22phosphoS22AntibodyProperties

Description

Anti-ARHGAP22pS22(RABBIT)Antibody-600-401-J11

Host

Rabbit

TargetSpecies

Mouse

KnownCrossReactivity

Human,Mouse,Rat

Clonality

Polyclonal

Application

ELISA:1:20,000-1:60,000
IFMicroscopy:1:100-1:500
WesternBlot:1µg/ml
Immunohistochemistry:1:100-1:500
OtherDilution:UserOptimized

PhysicalState

Liquid(sterilefiltered)

ShippingCondition

DryIce

Format

IgG

Label

Unconjugated

Concentration

1.07mg/mlbyUVabsorbanceat280nm

Buffer

0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2

Preservative

None

Stabilizer

50%(v/v)Glycerol

GeneName

ARHGAP22

RelevantLinks

UniProtKB-Q8BL80
NCBI-NP_722495
GeneID-239027

ARHGAP22phosphoS22AntibodyDescription

Background

ARHGAP22isaRhoGTPase-activatingproteininvolvedinthesignaltransductionpathwaythatregulatesendothelialcellcapillarytubeformationduringangiogenesis.ItactsasaGTPaseactivatorforRAC1byconvertingittoaninactiveGDP-boundstateandalsoinhibitsRAC1-dependentlamellipodiaformation.ItmayalsoplayaroleintranscriptionregulationviaitsinteractionwithVEZF1,byregulatingactivityoftheendothelin-1(EDN1)promoter.Anti-ARHGAP22[pSer22]antibodyisidealforresearchersinterestedinDiabetesResearch,LipidandMetabolismresearch.

Synonyms

rabbitanti-ARHGAP22pS22Antibody,Rho-typeGTPase-activatingprotein22,RHOGAP2,RhoGTPaseactivatingprotein22,rhoGTPase-activatingprotein22,ARHGAP22,ARHGAP-22

Immunogen

ARHGAP22affinitypurifiedantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithasyntheticphospho-peptidecorrespondingtotheregionsurroundingmousepS22regionofARHGAP22.

ImmunogenType

Peptide

PostTranslationalModification

Phosphorylation

StorageCondition

Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.

ApplicationNote

Anti-ARHGAP22pS22antibodyisusefulforELISA,WesternBlotandImmunostaining.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandapproximately~77.8kDacorrespondingtotheappropriatecelllysateorextract.

Purity/Specifity

Anti-ARHGAP22pS22wasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.ThisantibodyisspecificforphosphorylatedARHGAP22atSerine22.ItalsorecognizestheS397->AmutationbutnottheS22->Amutation.ABLASTanalysiswasusedtosuggestcross-reactivitywithMouse,RatandHumanbasedon100%sequencehomology.Cross-reactivitywithARHGAP22pS22fromothersourceshasnotbeendetermined.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.Theprospectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

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Rockland/ARHGAP22 phospho S22 Antibody/600401J11/50 µg

ARHGAP22phosphoS22AntibodyProperties

ARHGAP22phosphoS22AntibodyDescription