
Rockland的高特异性Epi-Plus™抗体可识别经过修饰的组蛋白和相关的细胞靶点,并通过多种检测方法进行验证。Epi-Plus™抗体对这种修饰是特别灵敏和特异的,并且对相同位点或该蛋白其他氨基酸的其他修饰没有交叉反应。免疫荧光显微技术(IF)、免疫沉淀(IP)、染色质免疫沉淀(ChIP)、免疫组织化学(IHC)和蛋白印迹(WB)的分析验证了Epi-Plus™抗体的有效性。
翻译后修饰(PTM)如组蛋白的甲基化、乙酰化和磷酸基化等都是调节基因表达调控、DNA修复、染色体凝缩和精子形成的关键部分。许多蛋白质已经被确认形成了复合物,能够调节组蛋白修饰。这个多组件的细胞机器被称为“读者、作家和橡皮擦”。这些组蛋白修饰复合物的功能变化被认为破坏了组蛋白标记的结构和水平,从而解除了基于核染色质的过程控制,最终导致致癌转化和癌症的发展。与此一致的是,组蛋白PTM的异常模式与大量的人类恶性肿瘤有关。Rockland提供了针对大多数修饰和修饰对的抗体。
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| 图为组蛋白翻译后修饰图 |
Rockland提供染色质和核信号抗体的组合,是表观遗传学研究的高品质试剂。在严格的质量控制测试下,Rockland生产抗组蛋白PTMs的抗体。这种Epi-Plus抗体是经过多种试验验证的,包括利用修饰过的肽阵、westernblots和染色质免疫沉淀(ChIP)进行的斑点印迹检测。这确保成品符合或超过我们的高标准,以达到最佳的性能。
用于Histone3K4甲基化
| 厂商 | 货号 | 名称 |
| Rockland | 600-401-I57 | Anti-HistoneH3[MonomethylLys4](RABBIT)Antibody |
| Rockland | 600-401-I58 | Anti-HistoneH3[DimethylLys4](RABBIT)Antibody |
| Rockland | 600-401-I59 | Anti-HistoneH3[TrimethylLys4](RABBIT)Antibody |
| 货号 | 名称 | 规格 | 种属反应 |
| 600-401-I52 | HistoneH3R2me1Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I53 | HistoneH3R2me2aAntibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I54 | HistoneH3K4me1/pT3Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I55 | HistoneH3K4me2/pT3Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I56 | HistoneH3pT3/K4acAntibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I57 | HistoneH3K4me1Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I58 | HistoneH3K4me2Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I59 | HistoneH3K4me3Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I60 | HistoneH3K4acAntibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I61 | HistoneH3K4me1/pT6Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I62 | HistoneH3K4me3/pT6Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I63 | HistoneH3pT6Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I64 | HistoneH3K9me1/pT6Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I65 | HistoneH3K9me2/pT6Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I66 | HistoneH3K9me3/pT6Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I67 | HistoneH3R8me2aAntibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I68 | HistoneH3R8me2sAntibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I69 | HistoneH3K9me1Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I70 | HistoneH3K9me2Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I71 | HistoneH3K9me3Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I72 | HistoneH3K9acAntibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I73 | HistoneH3K9ac/K14acAntibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I74 | HistoneH3pS10Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I75 | HistoneH3pS10/pT11Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I76 | HistoneH3pT11Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I77 | HistoneH3R17me2aAntibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I78 | HistoneH3K18me1Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I79 | HistoneH3K18me2Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I80 | HistoneH3K18me3Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I81 | HistoneH3K18acAntibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I82 | HistoneH3K23acAntibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I83 | HistoneH3pS28Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I84 | HistoneH3K27me3/pS28Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I85 | HistoneH3R2me2s/K4me2 Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I86 | HistoneH3K36me1Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I87 | HistoneH3K36me2Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I88 | HistoneH3K36me3Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I89 | HistoneH3K36acAntibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I90 | HistoneH3K37me1Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I91 | HistoneH3K37me2Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I92 | HistoneH3K37me3Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I93 | HistoneH3K56me1Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I94 | HistoneH3K56me3Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-I95 | HistoneH3K79Me3Antibody | 50ug | Human,mouse,C.elegans,rat,chicken, Xenopus,Drosophila,plant |
| 600-401-J98 | HistoneH3K4-Me3/K9-AcAntibody | 50ug | Human,mouse,rat,C.elegans |
| 600-401-J99 | HistoneH3K27me3Antibody | 50ug | Human,mouse,rat,C.elegans |
| 600-401-K00 | HistoneH3K27acAntibody | 50ug | Human,mouse,rat,C.elegans |
| 600-401-K01 | HistoneH3K4me2/pT6Antibody | 50ug | Human,mouse,rat,C.elegans |
| 600-401-K02 | HistoneH3K23me2Antibody | 50ug | Human,mouse,rat,C.elegans |
| 600-401-M75 | HistoneH3K27methylAntibody | 50ug | Human,mouse,rat,C.elegans |
| 600-401-P08 | HistoneH3K9-Ac/pS10 (RABBIT)Antibody | 50ug | Human |
| 600-401-P10 | HistoneH3K79-Me1Antibody | 50ug | Human,Mouse,Primate,C.elegans, Drosophila,Plant,Rat,Xenopus |
| 600-401-P14 | HistoneH3pT3/R2-Me2sAntibody | 50ug | Human |
| 600-401-V34 | HistoneH3K27me2Antibody | 50ug | Human |
| 600-401-W54 | HistoneH3K27me1Antibody | 50ug | Human |