Rockland/AID Antibody/600401G74/100 µg

AIDAntibodyProperties

Description

Anti-AID(RABBIT)Antibody-600-401-G74

Host

Rabbit

TargetSpecies

Human

KnownCrossReactivity

Human,Mouse

Clonality

Polyclonal

Application

WesternBlot:1-2ug/mL

PhysicalState

Liquid(sterilefiltered)

ShippingCondition

DryIce

Format

IgG

Label

Unconjugated

Concentration

1mg/mLbyUVabsorbanceat280nm

Buffer

0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2

Preservative

0.01%(w/v)SodiumAzide

GeneName

AID

RelevantLinks

NCBI-AAM95402
UniProtKB-Q8NFC5

AIDAntibodyDescription

Background

AIDantibodydetectshumanAID.Activation-inducedcytidinedeaminase(AID)wasinitiallydiscoveredasahomologoftheapolipoproteinBRNA-editingcytidinedeaminase1(APOBEC1)thatshowedcytidinedeaminasepropertiesinstimulatedBcelllines.ItisnecessaryforsomatichypermutationandclassswitchrecombinationinBcells,butinappropriateordysregulatedexpressionAIDisoftenfoundintumorsandBcellneoplasms.AlthoughitisstructurallyandfunctionallysimilartotheAPOBECproteins,itappearsunlikelythatAIDdeaminatesdCtodUresiduesinHIVcDNAasdoesAPOBEC3G.Anti-AIDantibodiesareidealforinvestigatorsinvolvedinApolipoproteinandInfectiousDiseaseresearch.

Immunogen

AIDAntibodywasproducedfromwholerabbitserumpreparedbyrepeatedimmunizationswithapeptidecorrespondingtoaminoacidsnearthec-terminusofhumanAID.

ImmunogenType

Peptide

StorageCondition

Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.

ApplicationNote

Anti-AIDAntibodyissuitableforuseinE,WB,andICC.Expectabandapproximately~23.9kDaonspecificlysates.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.

Purity/Specifity

Anti-AIDAntibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitypurification.ABLASTanalysiswasusedtosuggestcross-reactivitywithAIDwithHumanandMousebasedon100%homologywiththeimmunizingsequence.Cross-reactivitywithAIDfromothersourceshasnotbeendetermined.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.Theprospectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

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Rockland/AID Antibody/600401G74/100 µg

AIDAntibodyProperties

AIDAntibodyDescription