Rockland/ARC Antibody/600401Y56/100 µg

ARCAntibodyProperties

Description

Anti-ARC(RABBIT)Antibody-600-401-Y56

Host

Rabbit

TargetSpecies

Human

KnownCrossReactivity

Human,mouse,rat

Clonality

Polyclonal

Application

ELISA:1:50,000
WesternBlot:1:5,000

PhysicalState

Liquid(sterilefiltered)

ShippingCondition

DryIce

Format

IgG

Label

Unconjugated

Concentration

1mg/mLbyUVabsorbanceat280nm

Buffer

0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2

Preservative

0.02%(w/v)SodiumAzide

Stabilizer

None

GeneName

NOL3

RelevantLinks

UniProtKB-O60936
GeneID-8996
NCBI-NP_003937

ARCAntibodyDescription

Background

Apoptosisisregulatedbydeathdomain(DD)and/orcaspaserecruitmentdomain(CARD)containingmoleculesandacaspasefamilyofproteases.CARDcontainingcelldeathregulatorsincludeRAIDD,RICKBCL10,Apaf-1,caspase-9,andcaspase-2.AnovelCARDdomaincontainingproteinwasrecentlyidentifiedanddesignatedARCforapoptosisrepressorwithCARD.ARCinteractswithcaspase-2and-8andinhibitsenzymaticactivityofcaspase-8.ARCsuppressesapoptosisinducedbycelldeathadaptersFADDandTRADDandbycelldeathreceptorsFas,TNFR-1,andDR3.ThemessengerRNAofARCisprimarilyexpressedinskeletalmuscleandcardiactissue.

Synonyms

ARCAntibody,ARC,FCM,MYP,NOP,NOP30,ARC,Nucleolarprotein3,ApoptosisrepressorwithCARD,Myp

Immunogen

Anti-ARCantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswitha17aminoacidpeptideneartheN-terminusofhumanARC.

ImmunogenType

Peptide

StorageCondition

Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.

ApplicationNote

Anti-ARCAntibodyhasbeentestedforuseinELISAandWesternBlotting.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandatapproximately24kDainWesternBlotsofspecificcelllysatesandtissues.

Purity/Specifity

Anti-ARCAntibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.CrossreactivitywithARCfromothersourceshasnotbeendetermined.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.Theprospectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

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Rockland/ARC Antibody/600401Y56/100 µg

ARCAntibodyProperties

ARCAntibodyDescription