Rockland/Amyloid Oligomers (A11) Antibody/200401E88/100 µL

AmyloidOligomers(A11)AntibodyProperties

Description

Anti-AmyloidOligomers(A11)(RABBIT)Antibody-200-401-E88

Host

Rabbit

TargetSpecies

Human

KnownCrossReactivity

Human,Mouse,Rat

Clonality

Polyclonal

Application

ELISA:0.1-10µg/mL
WesternBlot:1:1000
Immunohistochemistry:1:1000-10,000
ImmunoPrecipitation:1:1000

PhysicalState

Liquid(sterilefiltered)

ShippingCondition

DryIce

Format

IgG

Label

Unconjugated

Concentration

0.5mg/mLbyUVabsorbanceat280nm

Buffer

0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2

Preservative

0.09%(w/v)SodiumAzide

Stabilizer

50%(v/v)Glycerol

GeneName

APP

RelevantLinks

NCBI-NM_000484.3

AmyloidOligomers(A11)AntibodyDescription

Background

Amyloidmonomericproteinscansometimesoligomerizeintodestructiveamyloidfibrils.Amyloidogenicconformationsofnon-diseaserelatedproteinscanbecreatedbypartialproteinmisfoldingordenaturation.Manydegenerativediseasesareknowntoberelatedtotheaccumulationofmisfoldedproteinsasamyloidfibres.Theseincludetheamyloid-ßpeptideplaquesandtauneurofibrillarytanglesinsenileplaquesofAlzheimer’ssymptomology,thedepositionofa-synucleinintheLewybodiesofParkinson’sdisease,andaccumulationofpolyglutamine-containingaggregatesinHuntington’sdisease.

Synonyms

AmyloidOligomeraß,A11,AmyloidbetaA4protein,ABPP,APPI,Alzheimerdiseaseamyloidprotein,Cerebralvascularamyloidpeptide,PreA4,Proteasenexin-II,APP,A4,AD1

Immunogen

AmyloidOligomers(A11)Antibodywasproducedfromwholerabbitserumpreparedbyrepeatedimmunizationswithsyntheticmolecularmimicofsolubleoligomers.

ImmunogenType

Peptide

StorageCondition

Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.

ApplicationNote

Anti-AmyloidFibrils(OC)AntibodyissuitableforuseinIP,IFmicroscopy,IHC,ELISA,WB,andDotblot.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.

Purity/Specifity

Anti-AmyloidOligomers(A11)AntibodywaspurifiedbyProteinAchromatography.ABLASTanalysiswasusedtosuggestcross-reactivitywithAmyloidOligomers(A11)fromEukaryotes,Human,Mouse,andRatbasedon100%homologywiththeimmunizingsequence.Recognizesalltypesofamyloidoligomers.Appearstorecognizeapeptidebackboneepitopethatiscommontoamyloidoligomers,butisnotfoundinnativeproteins,amyloidogenicmonomerormatureamyloidfibrils.Cross-reactivitywithAmyloidOligomers(A11)fromothersourceshasnotbeendetermined.Neuroscienceresearch.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.Theprospectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

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Rockland/Amyloid Oligomers (A11) Antibody/200401E88/100 µL

AmyloidOligomers(A11)AntibodyProperties

AmyloidOligomers(A11)AntibodyDescription