Rockland/ACVR1B Antibody/600401X67/100 µg

ACVR1BAntibodyProperties

Description

Anti-ACVR1B(RABBIT)Antibody-600-401-X67

Host

Rabbit

TargetSpecies

Human

KnownCrossReactivity

Human,mouse

Clonality

Polyclonal

Application

ELISA:1:10,000
WesternBlot:1µg/mL

PhysicalState

Liquid(sterilefiltered)

ShippingCondition

DryIce

Format

IgG

Label

Unconjugated

Concentration

1mg/mLbyUVabsorbanceat280nm

Buffer

0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2

Preservative

0.02%(w/v)SodiumAzide

Stabilizer

None

GeneName

ACVR1

RelevantLinks

UniProtKB-Q04771
GeneID-90
NCBI-NP_001096

ACVR1BAntibodyDescription

Background

Activinsaredimericgrowthanddifferentiationfactorswhichbelongtothetransforminggrowthfactor-beta(TGF-beta)superfamilyofstructurallyrelatedsignalingproteins.ActivinssignalthroughaheteromericcomplexofreceptorserinekinaseswhichincludeatleasttwotypeIandtwotypeIIreceptors.ACVR1B,alsoknownasactivinreceptor-likekinase4(ALK4),isatypeIreceptorforactivinandplaysmajorrolesincelldifferentiation,growtharrestandapoptosis.LikeanothertypeIactivinreceptorACVR1C,ACVR1BcanmediatesignalingbyligandssuchasNodal,Xnr1,GDF-1/3,activinBandactivinAB.InXenopusembryos,expressionofadominant-negativeformofACVR1Bblockedallmesoderm-inducingligands,whileexpressionofadominantnegativeACVR1ConlyblockedNodalandXnr1signaling,suggestingthattheACVR1BandACVR1Cpossessdistinctfunctions.

Synonyms

ACVR1BAntibody,FOP,ALK2,SKR1,TSRI,ACTRI,ACVR1A,ACVRLK2,Activinreceptortype-1,ActivinreceptortypeI,ACTR-I

Immunogen

Anti-ACVR1Bantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswitha14aminoacidsyntheticpeptideneartheC-terminusofthehumanACVR1B.

ImmunogenType

Peptide

StorageCondition

Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.

ApplicationNote

Anti-ACVR1BAntibodyhasbeentestedforuseinELISAandWesternBlotting.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandat~57kDainsizecorrespondingtothemolecularweightoftheACVR1BproteinbyWesternBlottingintheappropriatecelllysateorextract.

Purity/Specifity

Anti-ACVR1BAntibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.AtleastthreeisoformsofACVR1Bareknowntoexist.Thisantibodyispredictedtohavenocross-reactivitytoACVR1orACVR1C.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.Theprospectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

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Rockland/ACVR1B Antibody/600401X67/100 µg

ACVR1BAntibodyProperties

ACVR1BAntibodyDescription