Rockland/AIMP2 Antibody/600401X91/100 µg

AIMP2AntibodyProperties

Description

Anti-AIMP2(RABBIT)Antibody-600-401-X91

Host

Rabbit

TargetSpecies

Human

KnownCrossReactivity

Human

Clonality

Polyclonal

Application

ELISA:1:10,000-1:20,000
IFMicroscopy:Useroptimized
WesternBlot:1-2µg/mL
Immunohistochemistry:UserOptimized

PhysicalState

Liquid(sterilefiltered)

ShippingCondition

DryIce

Format

IgG

Label

Unconjugated

Concentration

1mg/mLbyUVabsorbanceat280nm

Buffer

0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2

Preservative

0.02%(w/v)SodiumAzide

Stabilizer

None

GeneName

AIMP2

RelevantLinks

UniProtKB-Q13155
GeneID-7965
NCBI-NP_006294

AIMP2AntibodyDescription

Background

AIMP2wasinitiallyidentifiedasapartofanaminoacyl-tRNAsynthesasecomplex(1).ItwaslaterdiscoveredtobeacofactorandsubstrateofParkin,aRing-typeE3ubiquitinligasethatisimportantforthesurvivalofdopamineneuronsinParkinson’sdisease;accumulationofAIMP2inthesecellsleadtocatecholaminergiccelldeath(2).AIMP2canalsobindtoTRAF2,akeyplayerintheTNF-alphasignalingpathway,causingtheubiquitinationofTRAF2bycIAP1,leadingtoTNF-alpha-dependentapoptosis(3).Finally,AIMP2hasbeensuggestedtofunctionasatumorsuppressor(4).

Synonyms

AIMP2Antibody,P38,JTV1,JTV-1,PRO0992,AminoacyltRNAsynthasecomplex-interactingmultifunctionalprotein2,Multisynthasecomplexauxiliarycomponentp38

Immunogen

Anti-AIMP2antibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswitha16aminoacidpeptideneartheinternalregionofhumanAIMP2.

ImmunogenType

Peptide

StorageCondition

Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.

ApplicationNote

Anti-AIMP2AntibodyhasbeentestedforuseinELISA,WesternBlotting,ImmunohistochemistryandImmunofluorescence.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandatapproximately36kDainWesternBlotsofspecificcelllysatesandtissues.

Purity/Specifity

Anti-AIMP2antibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.AIMP2antibodyishumanspecific.AIMP2antibodyispredictedtonotcross-reactwithAIMP1.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.Theprospectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

对照品标准品，生物试剂盒，gibco胎牛血清，试剂采购网，中国试剂网，细胞因子试剂盒

Rockland/AIMP2 Antibody/600401X91/100 µg

AIMP2AntibodyProperties

AIMP2AntibodyDescription