产品资料

Kerafast/Anti-ADAM19 (mouse), Cytoplasmic Domain Antibody/EHS010/100uL

ThisrabbitIgGpolyclonalantibodywasgeneratedagainsttheGST-ADAM19-cytoplasmictailandisspecificforthecytoplasmicdomainofmouseADAM19.

TheADAM(ADisintegrinAndMetalloproteaseDomain)familyisauniquegroupofproteinsthathastheABIlitytocleaveorshedextracellularportionsoftransmembraneproteins.Inaddition,ADAMsareinvolvedincell-cellandcell-matrixinteractions(e.g.,fertilization,muscledevelopmentandneurogenesis).

ADAM19,alsoknownasmeltrinß,wasfirstidentifiedinmusclecellsandlaterexpressedinothertissues(e.g.heart,lungandbone).ThecatalyticactivityofADAM19hasbeenexploredbytheoverexpressionincellsandbypurifyingrecombinantlyexpressedsolubleformsoftheectodomainorthepro-andmetalloproteinasedomains.ADAM19hasanimportantroleduringcardiovascularmorphogenesis.

FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.

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Specifications

ProductType:	Antibody
AccessionID:	AF019887
Antigen:	GST-ADAM19CytoplasmicDomain
MolecularWeight:	~120kDa
Isotype:	IgG
Clonality:	Polyclonal
Reactivity:	Mouse
Immunogen:	GST-fusionproteinwiththecytoplasmicdomainofmouseADAM19
SpeciesImmunized:	Rabbit
Epitope:	Cytoplasmicdomain
PurificationMethod:	Serum,notpurified
TestedApplications:	WB(1:500)
Storage:	-80C
Shipped:	Dryice

Research

Antibody	SpeciesReactivity	Specificity
ADAM9	Human	CytoplasmicDomain
ADAM9	Mouse	CytoplasmicDomain
ADAM12	Mouse	CytoplasmicDomain
ADAM15	Human	CytoplasmicDomain
ADAM15	Mouse	CytoplasmicDomain
ADAM15	Human	ExtracellularDomain
ADAM15	Mouse	DisintegrinDomain
ADAM17	Mouse	CytoplasmicDomain
ADAM17	Mouse	Prodomain
ADAM19	Mouse	CytoplasmicDomain
ADAM28	Mouse	CytoplasmicDomain
ADAM28	Mouse	ExtracellularDomain
SNX9	Mouse	CytoplasmicDomain

Data

WesternBlotAnalysis

WesternblotanalysisofmouseprimaryosteoblastsprobedwithwholeADAM19antiserumata1:500dilution.

Adaptedfrom:InoueE,etal.J.Biol.Chem.1998,273,4180-4187.

Provider

FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.

References

Inoue,D.;Reid,M.;Lum,L.;Krätzschmar,J.;Weskamp,G.;Myung,Y.M.;Baron,R.;Blobel,C.P.Cloningandinitialcharacterizationofmousemeltrinbetaandanalysisoftheexpressionoffourmetalloprotease-disintegrinsinbonecells.J.Biol.Chem.1998,273,4180-4187.
Chesneau,V.;Becherer,J.D.;Zheng,Y.;Erdjument-Bromage,H.;Tempst,P.;Blobel,C.P.CatalyticpropertiesofADAM19.J.Biol.Chem.2003,278,22331-22340.
Zhou,H.M.;Weskamp,G.;Chesneau,V.;Sahin,U.;Vortkamp,A.;Horiuchi,K.;Chiusaroli,R.;Hahn,R.;Wilkes,D.;Fisher,P.;Baron,R.;Manova,K.;Basson,C.T.;Hempstead,B.;Blobel,C.P.EssentialroleforADAM19incardiovascularmorphogenesis.Mol.Cell.Biol.2004,24,96-104.
Kawaguchi,N.;Horiuchi,K.;Becherer,J.D.;Toyama,Y.;Besmer,P.;Blobel,C.P.DifferentADAMshavedistinctinfluencesonKitligandprocessing:phorbol-ester-stimulatedectodomainsheddingofKitl1byADAM17isreducedbyADAM19.J.Cell.Sci.2007,120,943-952.

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AntigenName:	GST-ADAM19CytoplasmicDomain
AccessionID:	AF019887
MolecularWeight:	~120kDa
ImmunoglobulinIsotype:	IgG
Clonality:	Polyclonal
SpeciesReactivity:	Mouse
TypeofImmunogen:	GST-fusionproteinwiththecytoplasmicdomainofmouseADAM19
Epitope:	Cytoplasmicdomain
SpeciesImmunized:	Rabbit
PurificationMethod:	Serum,notpurified
TestedApplications:	WB(1:500)
StorageTemperature:	-80C
Shipped:	Dryice

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Kerafast/Anti-ADAM19 (mouse), Cytoplasmic Domain Antibody/EHS010/100uL

Data

References