| Clone: | 16E9 |
| Host: | Mouse |
| Isotype: | MouseIgG2a |
| Immunogen: | Syntheticpeptidecorrespondingtoaa5-16ofhumanamyloidβ-peptide. |
| UniProtID: | P05067 |
| Speciesreactivity: | Human |
| Applications: | ELISA |
| PurityDetail: | ProteinA/G-affinitypurified. |
| Formulation: | Liquid.In0.01Mphosphatebuffer,pH7.4,containing0.5Msodiumchlorideand15mMsodiumazide. |
| Shipping: | BlueIceNotFrozen |
| ShortTermStorage: | +4°C |
| ScientificBackground: | Beta-amyloid/Abetaisthemajorproteincomponentofneurofibrillarytanglesandsenileplaques,majorneuropathologicalhallmarksofAlzheimer"sdisease(AD).AbetaoccursintwopredominantformswithdifferentCOOH-termini,Abeta40andAbeta42.Abetaisgeneratedbyproteolyticcleavageoftheamyloidprecursorprotein(APP)attwositesbydistinctsecretases,thebeta-sitesecretaseBACE,andthemulti-subunitgamma-secretasecomposedofpresenilin,nicastrin,Aph-1,andPen-2. |
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