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Structural analog of acetylcholine that acts as a nicotinic agonist (Ki = 29.9 nM at α4β2). Upregulates the number of α4β2 binding sites in M10 cells in vitro by 440%.
| M. Wt | 284.14 |
| Formula | C8H17IN2O |
| Storage | Store at RT |
| CAS Number | 75667-84-4 |
| PubChem ID | 5311072 |
| InChI Key | VXBLRKDEHGKPAC-UHFFFAOYSA-M |
| Smiles | C[N+]1(C)CCN(CC1)C(=O)C.[I-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
| Solubility | Soluble to 100 mM in water |
The following data is based on the product molecular weight 284.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.52 mL | 17.6 mL | 35.19 mL |
| 5 mM | 0.7 mL | 3.52 mL | 7.04 mL |
| 10 mM | 0.35 mL | 1.76 mL | 3.52 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
References are publications that support the products' biological activity.
Spivak et al (1988) Binding of semirigid nicotinic agonists to nicotinic and muscarinic receptors. Mol.Pharmacol. 36 177 PMID: 2747625
Spivak et al (1986) Structural and electronic requirements for potent agonists at a nicotinic receptor. Eur.J.Pharmacol. 120 127 PMID: 3485051
Warpman et al (1998) Regulation of nicotinic receptor subtypes following chronic nicotinic agonist exposure in M10 and SH-SY5Y neuroblastoma cells. J.Neurochem. 70 2028 PMID: 9572289
Keywords: 4-Acetyl-1,1-dimethylpiperazinium iodide, supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Acetyldimethylpiperazinium, Nicotinic, Receptors, (Non-selective), Nicotinic, Receptors, (Non-selective), Tocris Bioscience
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