产品资料

Tocris/Pitavastatin calcium/4942/10/10 mg

Description: HMG-CoA reductase inhibitor

Alternative Names: NK-104

Chemical Name: (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid hemicalcium salt

Purity: ≥99% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Synthetic inhibitor of HMG-CoA reductase (K_i = 1.7 nM). Lowers low-density lipoprotein (LDL) cholesterol levels. Displays minimal metabolism by cytochrome P450 enzymes, with little involvement of CYP3A4. Shown to improve cardiac function and survival in a rat model of hypertensive heart failure.

Compound Libraries

Pitavastatin calcium is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	440.5
Formula	C₂₅H₂₃FNO₄.0.5Ca
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	147526-32-7
PubChem ID	5282451
InChI Key	RHGYHLPFVJEAOC-FFNUKLMVSA-L
Smiles	[Ca++].O[C@H](C[C@H](O)C=CC1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1)CC([O-])=O.O[C@H](C[C@H](O)C=CC1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1)CC([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.05	100

Preparing Stock Solutions

The following data is based on the product molecular weight 440.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.27 mL	11.35 mL	22.7 mL
5 mM	0.45 mL	2.27 mL	4.54 mL
10 mM	0.23 mL	1.14 mL	2.27 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Saka et al (2006) Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure. J.Cardiovasc.Pharmacol. 47 770 PMID: 16810078

Mukhtar et al (2005) Pitavastatin. Int.J.Clin.Pract. 59 239 PMID: 15854203

Aoki et al (1997) Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Arzneimittelforschung. 47 904 PMID: 9296275

Keywords: Pitavastatin calcium, supplier, NK-104, HMG, CoA, reductase, inhibitors, inhibits, synthetic, statins, NK-104, HMG-CoA, Reductase, HMG-CoA, Reductase, Tocris Bioscience

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