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| Description | CateninbetaisanadherensjunctionproteinandhasaroleintheregulationofcelladhesionandinsignaltransductionthroughtheWntpathway.Atleast2isoformsareproducedbyalternativesplicing. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µg |
| Antigen | Asyntheticpeptide(C-SNQLAWFDTDL)correspondingtotheaminoacidregion771-781ofhumanCateninbetacoupledtocarrierproteinKLH. |
| OtherNames | Cateninbeta-1;Beta-catenin;CTNNB1;CTNNB;_-Catenin; |
| Accession | P35222CTNB1_HUMAN; |
| Producedin | Sheep |
| Purity | Affinitypurified |
| Applications | WesternBlotting(WB)andImmunoprecipitation.Aconcentrationof1.0µg/mlisrecommendedforWB.HumanCateninbeta(isoform1)hasapredictedlengthof781residuesandMWof86kDa.Aconcentrationof5µg/500µgoflysateisrecommendedforimmunoprecipitation.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | ThespecificityofthisantibodyhasbeenconfirmedbyWBagainsttheantigen.Thisantibodywasalsovalidatedforimmunoprecipitationinratliverlysate(datanotshown). |
| Cross-reactivity | Human;mouse;rat; |
| Blastit | Ifyouwishtousethisproductinaspeciesotherthanthosespecifiedhereandwanttodeterminetheaminoacidsequencehomologybetweentheimmunogenandthecorrespondingproteininthatspecies,simplycopytheaminoacidsequenceforthisimmunogenandtestitontheBLASTdatabasethatyoucanaccessthroughthelinkbelow.Pleasenotethatantibodiesraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptide.Whatthismeansinpractiseisthatasingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.TheBLASTdatabasecanalsobeusedtocompareanyaminoacidsequencebetweenspeciesandbetweenprotein.ThefullaminoacidsequenceofthetargetproteincanbefoundbyfollowingthelinkintheAccessionfield.YoucanthensearchanyaminoacidsequenceinthetargetproteinusingtheBLASTdatabase.Whenselectingasequencetosearch,pleasechoosecarefully,asthesequenceyouchoosemaybeaprecursorratherthanthematureproteinforexample. |
| Form | Lyophilisedfrom10mMsodiumHEPES(pH7.5),150mMNaCl,and0.05%sodiumazide. |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Atleast12monthsafterpurchaseat2-4°C(lyophilizedformulations).Afterreconstitution,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles. |
| ExpiryDate | 12monthsafterpurchase |