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| Description | TISSUESPECIFICITY:Predominantlyexpressedintrigeminalanddorsalrootsensoryganglia.Isoform1andisoform3arealsoexpressedinbrainandperipheralbloodmononuclearcells. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | Asyntheticpeptide(YFSHLKEYVAS)ofhumancapsaicinreceptorprotein(aa:531-541)conjugatedtoKLHhasbeenusedastheimmunogen. |
| OtherNames | TransientreceptorpotentialcationchannelsubfamilyVmember1;TrpV1;Capsaicinreceptor;Osm-9-likeTRPchannel1;OTRPC1;Vanilloidreceptor1;TRPV1;VR1;VR-1; |
| Accession | Capsaicin_HUMAN |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | IHC.Useat1:1000to1:2000dilution.Thisantibodyhasnotbeentestedinotherapplications.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | ImmunohistochemicalanalysisofratDRGindicatesasuperbdegreeofspecificityforthisserum. |
| Cross-reactivity | ThisantibodyisknowntoreactwithratCapsaicinandduetosequencehomologyisexpectedtoreactwithmouseCapsaicin.Otherspecieshavenotyetbeentested. |
| Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedIDbetweentheimmunogenusedhereindifferentspeciesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstability,andat4ºCwithanappropriateantibacterialagent. |
| ExpiryDate | 12monthsafterpurchase |
| SpecificReferences | 1.RehmanRetal(2013)TRPV1inhibitionattenuatesIL-13mediatedasthmafeaturesinmicebyreducingairwayepithelialinjury.IntImmunopharmacol.2013Mar;15(3):597-605. |
| References | 1.Caterinaetal.Nature398:436(1999). 2.Tominagaetal.Neuron.21:531-543(1998). 3.Nagy,I.etal.EurJPharmacol500:351-369(2004). |