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Finda2platesizeofthisproducthere.Enquireaboutbulkdiscountsfortenormoreplates,atsales@Biosensis.com| Description | BatchNo. | Seeproductlabels | Antigen | BDNFbelongstotheneurotrophinfamilyandregulatesthesurvivalanddifferentiationofneuronsduringdevelopment.ThealterationsinBDNFexpressioninducedbyvariouskindsofbraininsultincludingstress,ischemia,seizureactivityandhypoglycemia,maycontributetosomepathologiessuchasdepression,epilepsy,Alzheimer"s,andParkinson"sdisease.FUNCTION:Promotesthesurvivalofneuronalpopulationsthatarealllocatedeitherinthecentralnervoussystemordirectlyconnectedtoit.MajorregulatorofsynaptictransmissionandplasticityatadultsynapsesinmanyregionsoftheCNS.TheversatilityofBDNFisemphasizedbyitscontributiontoarangeofadaptiveneuronalresponsesincludinglong-termpotentiation(LTP),long-termdepression(LTD),certainformsofshort-termsynapticplasticity,aswellashomeostaticregulationofintrinsicneuronalexcitABIlity.SUBUNIT:Monomersandhomodimers.BindstoNTRK2/TRKB.SUBCELLULARLOCATION:Secretedprotein.PostTranslationModification(PTM):ThepropeptideisN-glycosylatedandglycosulfated.PTM:ConvertedintomatureBDNFbyplasmin(PLG)(Bysimilarity).DISEASE:DefectsinBDNFareacauseofcongenitalcentralhypoventilationsyndrome(CCHS);alsoknownascongenitalfailureofautonomiccontrolorOndinecurse.CCHSisararedisordercharacterizedbyabnormalcontrolofrespirationintheabsenceofneuromuscularorlungdisease,oranidentifiablebrainstemlesion.AdeficiencyinautonomiccontrolofrespirationresultsininadequateornegligIBLeventilatoryandarousalresponsestohypercapniaandhypoxemia.CCHSisfrequentlycomplicatedwithneurocristopathiessuchasHirschsprungdiseasethatoccursinabout16%ofCCHScases.SIMILARITY:BelongstotheNGF-betafamily. | OtherNames | Brain-derivedneurotrophicfactor;BDNF;Abrineurin | Accession | P21237BDNF_MOUSE; | Producedin | ThestandardandimmunogenforthiskitisrecombinantBDNFproducedinandpurifiedfromaninsectcell(sf21)expressionsystem.Thisproteinsequenceisidenticalinhuman,mouse,rat,andmanyotherspecies. | Specificity | Mouse;Human;Rat; | Storage | Storeat4°C | SpecificReferences | SandraPetzold,BabetteSommer,AndreaKröber,RobertNitsch,HerbertSchwegler,JohannesVogt,ThomasRoskoden(2015)NT-3proteinlevelsareenhancedinthehippocampusofPRG1-deficientmicebutremainunchangedinPRG1/LPA2doublemutants.NeuroscienceLetters.doi:10.1016/j.neulet.2015.12.016. | Kitcomponents | TheELISAkitboxcontains1x96pre-coatedstripplates,proteinstandards,detectionreagents,substratebufferandpreciseinstructions. | Range | 31.2pg/ml-2,000pg/ml | Sensitivity | < 2pg/ml | Kitprotocol |  BEK-2003-1P_as_at_Aug2015_protocol.pdf
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