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| Description | Gremlin-1isasecretedcytokinethatmayplayaroleduringcarcinogenesisandmetanephrickidneyorganogenesis,asaBMPantagonistrequiredforearlylimboutgrowthandpatterninginmaintainingtheFGF4-SHHfeedbackloop.Itdown-regulatestheBMP4signalinginadose-dependentmanner.Italsoactsasinhibitorofmonocytechemotaxis.Itishighlyexpressedinsmallintestine,fetalbrainandcolon.Weaklyexpressedinbrain,ovary,prostate,pancreasandskeletalmuscle.Inbrainfoundintheregionlocalizedaroundtheinternalcapsuleinthelargesubcorticalnuclei,includingcaudate,putamen,substantianigra,thalamusandsubthalamus.Predominantlyexpressedinnormalcellsincludingneurons,astrocytesandfibroblasts.Gremlin-1isinducedthroughTGF-beta1-mediatedpathwaysinMesangialcellanditisdown-regulatedintumorcelllines. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µg |
| Antigen | PartialrecombinanthumanGremlin-1(75-184)withaGSTtag. |
| Isotype | IgG2aKappa |
| Clone | 4C2 |
| OtherNames | Cysteineknotsuperfamily1BMPantagonist1;Increasedinhighglucoseprotein2;IHG-2;Down-regulatedinMos-transformedcellsprotein;DANdomainfamilymember2;Cellproliferation-inducinggene2proteinGREM1;CKTSF1B1;DAND2;DRM |
| Accession | GREM1_HUMAN |
| Producedin | Mouse |
| Purity | ProteinGpurifiedimmunoglobulin |
| Applications | ThisantibodyisrecommendedforWBandsandwichELISA.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | SpecificityhasbeenconfirmedbyWBanddirectELISAagainsttheantigen. |
| Cross-reactivity | Human; |
| Blastit | Toseethesharedidentitybetweendifferentspeciesorotherproteins,followthelinkintheAccessionfield,selectthesequencethatyouareinterestedinandcopyandpasteitHEREandblast/formatit. |
| Form | LyophilisedfromPBSpH7.4 |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Lyophilisedantibodycanbestoredat-20ºC.Afterreconstitutionkeepaliquotsat-20ºCforhigherstabilityorat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |