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| Description | TheBcl-2familyofproteinswhichregulateapoptosisshareidenticalsequencescalledBcl-2Homologydomains(BH1-4).TheBH3proteins,includingBID,NOXA,PUMA,BIK,BIMandBADareallpro-apoptoticandsharesequenceidentitywithintheamphipathicalpha-helicalBH3region,whichisessentialfortheirapoptoticfunction.NOXAishighlyexpressedinadultT-cellleukemiacellline. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | Asyntheticpeptide(CAQLRRIGDKVNLRQK)aspartofmouseNoxa(aa:75-90)conjugatedtodiphtheriatoxoid |
| OtherNames | PMAIP1;phorbol-12-myristate-13-acetate-inducedprotein1;adultTcellleukemia-derivedPMA-responsive;Immediate-early-responseproteinAPR;PMA-inducedprotein1;Pmaip1;Noxa |
| Accession | NOXA_MOUSE |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | WB.Adilutionof1:1000to1:2000isrecommendedforthisapplication.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | WesternblotanalysisofcellsinfectedwithNoxaadenovirusesandBAFindicatesahighlevelofspecificityforthisantiserum. |
| Cross-reactivity | Thisantiserumcross-reactswithmouse.Notyettestedinotherspecies. |
| Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstability,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| References | 1.Jansson,A.K.,etal.,Oncogene22(30):4675-4678(2003). 2.Hijikata,M.,etal.,J.Virol.64(10):4632-4639(1990). |