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| Description | Thematrixmetalloproteinases(MMPs)arealargefamilyof zincendopeptidasesthat degradeextracellularmatrixcomponentssuchasfibronectinandcollagentypeIII.Thetissueinhibitorsofmetalloproteinase(TIMPs)complexwiththesematrixmetalloproteinasesandirreversiblyinactivatethem.TheTIMPproteinsare homologousandareeithersecretedinsolubleform(TIMP1,TIMP2andTIMP4)orbindtoextracellularmatrixcomponents(TIMP3).Metalloproteinaseinhibitor4(TIMP4)isknowntoinhibitMMP-1,MMP-2,MMP-3,MMP-7andMMP-9. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µg |
| Antigen | Asyntheticpeptide(YRGHLPLRKEFVDIVQP)correspondingtoaregion(208-224)fromtheC-terminusofhumanMetalloproteinaseinhibitor4.Toenhancetheimmunologicalresponse,thispeptidewascoupledtocarrierproteinBSA. |
| OtherNames | Tissueinhibitorofmetalloproteinases4;TIMP-4;TIMP4; |
| Accession | Q99727TIMP4_HUMAN; |
| Producedin | Rabbit |
| Purity | Affinitypurifiedonantigencolumn |
| Applications | WesternBlotting(WB).Aconcentrationof0.1-0.5µg/mlisrecommendedforWB.HumanTIMP4(precursor)hasapredictedlengthof224residuesandMWof26kDa.Aconcentrationof0.5-1.0µg/mlisrecommendedtodetecttheproteininformalinfixedandparaffinembeddedtissues.Heatmediatedantigenretrievalisrecommended.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | ThespecificityofthisantibodyhasbeenconfirmedbyWBandIHCagainsttheantigen. |
| Cross-reactivity | Human;rat;expectedtoreactwithmouseduetosequencehomology; |
| Form | Liquid(0.5ml)in50%glycerol,0.9mgNaCland0.2mgNa2HPO4 |
| Reconstitution | TheliquidformulationshouldbedilutedinPBS(pH7.4) |
| Storage | Afterreconstitution,aliquotandstoreat-20°Cforahigherstability.Avoidfreeze-thawcycles. |
| ExpiryDate | 12monthsafterpurchase |