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| Description | Alphasynucleinisanabundant140aminoacidneuronalprotein,expressedprimarilyatpresynapticterminalsinthecentralnervoussystem.Alphasynucleinhasbeenassociatedwithseveralneurodegenerativediseases.Apointmutationinthegenecodingforthealpha-synucleinproteinwasthefirstdiscoverylinkingthisproteintoararefamilialformofParkinsonsdisease(PD).Subsequently,othermutationsinthealpha-synucleingenehavebeenidentifiedinfamilialPD.TheaggregatedproteinaceousinclusionscalledLewybodiesfoundinPDandcorticalLewybodydementia(LBD)werediscoveredtobepredominantlyalpha-synuclein.Aberrantaggregationofalpha-synucleinhasbeendetectedinanincreasingnumberofneurodegenerativediseases,collectivelyknownassynucleopathies.Alpha-synucleinexistsphysiologicallyinbothsolubleandmembrane-boundstates,inunstructuredandalpha-helicalconformations,respectively.Thephysiologicalfunctionofalpha-synucleinappearstorequireitstranslocationbetweenthesesubcellularcompartmentsandinterconversionbetweenthe2conformations.Abnormalprocessingofalpha-synucleinispredictedtoleadtopathologicalchangesinitsbindingpropertiesandfunction. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µg |
| Antigen | Asyntheticpeptide(CMPVDPDNEAYEMPSEE)ofhumanalphasynucleinprotein(aa:116-131). |
| OtherNames | Non-AbetacomponentofADamyloid;Non-A4componentofamyloidprecursor;NACP |
| Accession | P37840SYUA_HUMAN; |
| Purity | Crude |
| Applications | ControlPeptide.Thispeptidemaybeusedtoblockthebindingactivityofantibodiestoalphasynuclein(seeBiosensisantibodiesS-024-100andS-075-50). |
| BlastURL | Clickhere |
| Form | Lyophilized |
| Reconstitution | ThispeptideissolubleinPBSandwater. |
| Storage | Afterreconstitutionkeepat-20ºC.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 24monthsafterpurchase |