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| Description | Neuronalacetylcholinereceptoriscomposedofalphaandbetasubunits.TheAlpha-4subunitcanbecombinedtobeta-2orbeta-4togiverisetofunctionalreceptors.Uponbindingofacetylcholine,theacetylcholinereceptorrespondsbyundergoinganextensivechangeofconformationaffectingallitssubunitsandleadtotheopeningofanion-conductingchannelacrosstheplasmamembrane.Neuronalacetylcholinereceptorsubunitalpha-4isatransmembraneproteinthatlocalisestothecelljunction,synapseandpostsynapticcellmembrane.Itbelongstotheligand-gatedionicchannelfamily.AbnormalitiesintheCHRNA4genecauseautosomaldominantnocturnalfrontallobeepilepsytype1.Thisdiseaseischaracterisedbyclustersofmotorseizuresduringsleep. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µg |
| Antigen | Thisantibodywasraisedagainstapartialrecombinantproteinofhumanneuronalacetylcholinereceptorsubunitalpha-4(aminoacids29to128)withaGSTtag. |
| Clone | [4E3] |
| OtherNames | CHRNA4 |
| Accession | ACHA4_HUMAN |
| Producedin | Mouse |
| Purity | ProteinGpurifiedimmunoglobulin |
| Applications | ThisantibodyisrecommendedforWBanddirectELISA.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | ThespecificityofthisantibodywasconfirmedbyWBanddirectELISAagainsttheantigen. |
| Cross-reactivity | Otherspecieshavenotbeentested. |
| Blastit | Ifyouwouldliketoseethesharedidentitybetweendifferentspeciesorotherproteins,followthelinkintheAccessionfield,selectthesequence(makesurethatyouareselectingthesequencethatyouareinterestedin,asthesequencemaybetheprecursorratherthanthematureproteinforexample)andcopyandpasteitHEREandblast/formatit. |
| Form | LyophilisedfromPBSpH7.2 |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforhigherstabilityorat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |