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| Description | Proopiomelanocortin(POMC)istheprecursorofthemelanocortinpeptidesalpha,betaandgamma.POMCneuronsinthearcuatenucleusofthehypothalamusfunctionaskeycentralregulatorsoffoodintakeandhomeostaticcontrolofenergybalanceinbothrodentsandnon-humanprimates.MSHincreasesthepigmentationofskinbyincreasingthemelaninproductioninmelanocytes.MSHisproducedinthepituitaryglandandbelongstothePOMCfamily. |
| BatchNo. | Seeproductlabel |
| Unitsize | 50µl |
| Antigen | Asyntheticpeptide(Ac-SYSMEHFRWGKPV)correspondingtotheaminoacids138-150fromhumanProopiomelanocortin(POMC).POMCistheprecursorofthemelanocortinpeptidesalpha,betaandgamma.Thesyntheticpeptidewasconjugatedtoacarrierproteintoenhancetheimmunologicalresponse. |
| OtherNames | Proopiomelanocortin;POMC;alpha-melanocytestimulatinghormone;melanotropinalpha |
| Accession | COLI_HUMAN |
| Producedin | Guineapig |
| Purity | Neatserum |
| Applications | IHC.Aconcentrationof1in2,000isrecommendedforIHC.IHCperformedinsheepbrain(hypothalamus)demonstratesintensestainingofcells.Nostainingisevidentwhentheprimaryantibodyispre-absorbedwith0.5mg/mlofalphaMSH.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Specificitywasdemonstratedbyimmunohistochemistry. |
| Cross-reactivity | Thisantibodyisknowntoreactwithhuman,ratandsheep.Otherspecieshavenotyetbeentested. |
| Blastit | Ifyouwouldliketoseethesharedidentitybetweendifferentspeciesorotherproteins,followthelinkintheAccessionfield,selectthesequence(makesurethatyouareselectingthesequencethatyouareinterestedin,asthesequencemaybetheprecursorratherthanthematureproteinforexample)andcopyandpasteitHEREandblast/formatit. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein50µlsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Itisrecommendedthatathawedsampleisstoredat4ºCfornolongerthan2weeks.Allocationofappropriateanti-bacterialagentcanincreaseshelflifebyseveralweeks.Dilutedserumshouldbepreparedasrequired.Longtermstabilityrequiresstorage,preferablyinsmallaliquotsat-20ºCorlower.Glycerol(1:1)canbeaddedtoneatserumforadditionalstabilityifintendedusedoesnotpreventthis. |
| ExpiryDate | 12monthsuponreconstitution. |
| GeneralReferences | CardosoRC,AlvesBR,SharptonSM,WilliamsGL,AmstaldenM(2015).NutritionalProgrammingofAcceleratedPubertyinHeifers:InvolvementofPro-OpiomelanocortinNeuronesintheArcuateNucleus.JNeuroendocrinol.2015Aug;27(8):647-57. GraysonBE,AllenSE,BillesSK,WilliamsSM,SmithMS,GroveKL(2006).Prenataldevelopmentofhypothalamicneuropeptidesystemsinthenonhumanprimate.Neuroscience.2006Dec28;143(4):975-86. |