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Exalpha/Mouse anti Neurofilament 200 kD/MUB1308P/.1 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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产品资料

Exalpha/Mouse anti Neurofilament 200 kD/MUB1308P/.1 mg

ProductCode

ProductName

MouseantiNeurofilament200kD

Size

.1mg

Price(USD)

$310

Background

Likemostotherintermediatefilamentproteins(IFPs),theexpressionofthedifferentneuronalIFPsisbothtissue-specificanddevelopmentallyregulated.Theneurofilament(NF)tripletproteins(70,160,and200kDa)occurinboththecentralandperipheralnervoussystemandarenormallyrestrictedtoneurons.The70kDaNF-proteincanself-assembleintoafilamentousstructure,whereasthe160kDaand200kDaNF-proteinsrequirethepresenceofthe70kDaNF-proteintoco-assemble.AllthreeNFproteinscanbedetectedbyimmunohistochemicalmethodsatday9or10aftergestationintheMouseembryo.AlthoughIFPsoftheneurofilamenttypearenormallyrestrictedtoneurons,therearereportsontheirexpressioninnon-neuronalcellsaswell.Forexample,inheartconductionmyocytesNFproteinsareexpressedtogetherwithdesmin.Intumorpathologyganglioneuroblastomasandsomeoftheotherneuroblastomasarestronglypositivewiththeneurofilamentantisera.Also,someneuro-endocrinemalignanciesmayshowNFpositivity.Incellculturesofneuraltissuestheneurofilamentantibodiescanmonitorinvitrodifferentiation.

Host

Mouse

Isotype

IgG2a

SpeciesReactivity

Bovine,Canine,Chicken,GuineaPig,Hamster,Human,Monkey,Mouse,Rabbit,Rat,Sheep,Xenopus,Zebrafish

ProductUsage

RNF405reactsexclusivelywiththephosphorylatedisoformofthe200kDneurofilamentprotein.

ProductType

PrimaryAntibodies

Applications

Immunohistochemistry(frozen),Immunohistochemistry(paraffin),Westernblotting

FieldsofInterest

Cytoskeleton,NeuroBIOLOGy,Stemcellresearch

ProductSource

RNF405isaMousemonoclonalIgG2aantibodyderivedbyfusionofSP2/0-Ag14MousemyelomacellswithspleencellsfromaMouseimmunizedwithaneurofilamentpreparationofcalfbraintissue.

ProductFormulation

Eachvialcontains100ul1mg/mlpurifiedmonoclonalantibodyinPBScontaining0.09%sodiumazide.

StorageConditions

Storeat4
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