Tested Species Reactivity:HumanPredicted Species Reactivity:Mouse, Rat, Bovine, Chicken, Porcine, Rabbit, SheepProduct Format:Liquid. Borate buffered saline, pH 8.2Clonality:PolyclonalHost:GoatConjugation:UNLB: UnconjugatedApplication:EM, ICC, IHC-F, IHC-P, IP, WBAdditional Information:Description: Pooled antisera from goats hyperimmunized with type II collagen; purified by affinity chromatography on type II collagen covalently linked to agarose; reacts with conformational determinants on type II collagen; cross-adsorbed against Collagen types I, III, IV, V, and VI for minimal reactivityReconstitution and Storage:Store at 2-8CImmunogen:Type II collagenConcentration:0.4 mg/mLDatasheets/Manuals:Printable datasheet for OASB02740Specificity:Type II CollagenGene Symbol:COL2A1Official Gene Full Name:collagen type II alpha 1 chainAlias Symbols:AOM, ANFH, SEDC, STL1, COL11A3NCBI Gene Id:1280Protein Name:collagen alpha-1(II) chainDescription of Target:This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.Swissprot Id:P02458Protein Accession #:NP_001835.3Nucleotide Accession #:NM_001844.4Tissue Tool:Find tissues and cell lines supported by DNA array analysis to express COL2A1. RNA Seq:Find tissues and cell lines supported by RNA-seq analysis to express COL2A1.