产品资料

Sino Biological/TGFBI Protein, Human, Recombinant (His Tag)/1/10569-H08H

Description
Related Products
Citations
Protein Expression Service

TGFBI Protein, Human, Recombinant (His Tag): Product Information

Purity

> 75 % as determined by SDS-PAGE

Endotoxin

< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">

Activity

Testing in progress

Protein Construction

A DNA sequence encoding the extracellular domain of human beta IG-H3 (NP_000349.1) precursor (Met 1-His 683) was expressed, fused with a polyhistidine tag at the C-terminus.

Accession#

NP_000349.1

Expressed Host

HEK293 Cells

Species

Human

Predicted N Terminal

Gly 24

Molecule Mass

The secreted recombinant human beta IG-H3 comprises 671 amino acids with a predicted molecular mass of 74 kDa. As a result of glycosylation, the apparent molecular mass of rh beta IG-H3 is approximately 65 kDa in SDS-PAGE under reducing conditions.

Formulation

Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.

Please refer to the specific buffer information in the hard copy of CoA.

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Stability & Storage

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Reconstitution

A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TGFBI Protein, Human, Recombinant (His Tag): Images

TGFBI Protein, Human, Recombinant (His Tag): Synonyms

BIGH3 Protein, Human; CDB1 Protein, Human; CDG2 Protein, Human; CDGG1 Protein, Human; CSD Protein, Human; CSD1 Protein, Human; CSD2 Protein, Human; CSD3 Protein, Human; EBMD Protein, Human; LCD1 Protein, Human

TGFBI Background Information

TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. TGFBI plays a role in cell-collagen interactions and may be involved in endochondral bone formation in cartilage. TGFBI is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in TGFBI are associated with multiple types of corneal dystrophy. TGFBI can bind to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, TGFBI may be involved in endochondral bone formation. Loss of the TGFBI is sufficient to induce specific resistance.

Full Name

transforming growth factor, beta-induced, 68kDa

References

Kannabiran C, et al. (2006) TGFBI gene mutations in corneal dystrophies. Hum Mutat. 27(7): 615-25.

Matrix metalloproteinase 9 (MMP-9)-dependent processing of βig-h3 protein regulates cell migration, invasion, and adhesion
Author
Kim, YH;Kwon, HJ;Kim, DS;
Year
2012
Journal
J. Biol. Chem.
Application
binding/cell-based
PubMed ID: 23019342 FoldedExpand
Ex vivo Expansion of Human Limbal Epithelial Cells Using Human Placenta-derived and Umbilical Cord-derived Mesenchymal Stem Cells
Author
Nam, SM;Maeng, YS;Kim, EK;Seo, KY;Lew, H;Lew, H;
Year
2017
Journal
Stem Cells International
Application
cell-based(culture)
PubMed ID: 28894469FoldedExpand
Role of TGFBIp in Wound Healing and Mucin Expression in Corneal Epithelial Cells
Author
Maeng, YS;Lee, GH;Lee, B;Choi, SI;Kim, TI;Kim, EK;
Year
2017
Journal
Yonsei Med. J
Application
cell-based (migration)
PubMed ID: 28120575FoldedExpand
肿瘤相关巨噬细胞分泌转化生长因子⁃ β 诱导蛋白影响胶质瘤干细胞特性的体外研究
Author
朱洪涛, ;刘丹, ;陈籽荣, ;厉亚坤, ;王震, ;程芳玲, ;
Year
2020
Journal
中国现代神经疾病杂志
Application
IF; IHC
FoldedExpand

对照品标准品，生物试剂盒，gibco胎牛血清，试剂采购网，中国试剂网，细胞因子试剂盒

Sino Biological/TGFBI Protein, Human, Recombinant (His Tag)/1/10569-H08H

Description

Related Products

Citations

Protein Expression Service

TGFBI Protein, Human, Recombinant (His Tag): Product Information

TGFBI Protein, Human, Recombinant (His Tag): Images

TGFBI Protein, Human, Recombinant (His Tag): Synonyms

TGFBI Background Information

Citation List

If you couldn"t find the specific citation, you can:

E.coli protein expression service

Mammalian transient protein expression service

Baculovirus-insect expression service

Stable cell line development service (CHO / HEK293)