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Axon 2175
CAS [18550-98-6]
MF C13H10N2OMW 210.23
Inhibitor of HIF-1-induced PFKFB3, an enzyme with a key role in glycolysis. Potential application as suppressor of tumor glucose metabolism and growth of non-small cell lung cancer cells. The PFKFB3 family member has the highest kinase:bisphosphatase ratio (740:1) of the four known PFKFB family members. 3PO markedly attenuated the stimulation of F2,6BP synthesis, 2-[1-14C]-deoxy-D-glucose uptake, lactate secretion, TNF-α secretion and T cell aggregation and proliferation.
KEYWORDS: 3PO | supplier | PFKFB3 inhibitor | 3PO | 3PO | CAS [18550-98-6] | Fructose 6-phosphate | PFKFB3 | F6P | F2 | 6BP | Inhibitor | Enzymes
| S Telang et al. Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation. J. Trans. Med. 2012, 10, 95. |
| B Clem et al. Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol. Cancer. Ther. 2008, 7, 110-120. |
(E)-3-(pyridin-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one
[18550-98-6]
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