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axonmedchem/4μ8C/10 mg/Axon 1902

4μ8C

Based on 47 publications in PubMed101047

Axon 1902

CAS [14003-96-4]

MF C11H8O4MW 204.18

  • Purity:99%
  • Soluble in DMSO

4μ8C

Description

Potent and selective IRE1 α inhibitor (IC50: 60 nM). 4μ8C blocks substrate access to the active site of IRE1 and selectively inactivates both Xbp1 splicing and IRE1-mediated mRNA degradation.

KEYWORDS: 4μ8C | Supplier | 14003-96-4 | Axon 1902 | 4mu8C | 4u8C | IRE1 inhibitor | Axon Medchem | Axon1902 | IRE1α | splicing | RNA degradation

  • References
  • Certificates
  • Categories
  • Extra info
BC Cross et al. The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc. Natl. Acad. Sci. USA. 2012, 109(15), E869-78.
  • Certificate of Analysis
  • Material Safety Data Sheet
ApoptosisCell Signaling & OncologyEC 2.7.11.1IRE
IRE1α inhibitor

Chemical name

7-hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde

Parent CAS No.

[14003-96-4]

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