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axonmedchem/A 66/5 mg/Axon 1831188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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axonmedchem/A 66/5 mg/Axon 1831

A 66

Based on 8 reference(s) in Google Scholar9108

Axon 1831

CAS [1166227-08-2]

MF C17H23N5O2S2MW 393.53

  • Purity:99%
  • Optical purity:Optically pure
  • Soluble in DMSO

A 66

Description

Potent and specific PI3K p110α inhibitor (IC50: 32 nM); highly selective for p110α over other PI3Ks and having a high degree of specificity as it does not target other protein kinases tested; highly recommended tool in researching p110α isoform
  • References
  • Certificates
  • Categories
  • Extra info
S Jamieson et al. A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochem J. 2011, 438(Pt 1), 53–62.
Ashley J. Waardenberg et al. Phosphoinositide 3-Kinase (PI3K(p110α)) Directly Regulates Key Components of the Z-disc and Cardiac Structure. J. Biol. Chem. 2011, 286, 30837-30846.
  • Certificate of Analysis
  • Material Safety Data Sheet
Cell Signaling & OncologyPI3KPI3K-Akt-mTOREC 2.7.1.153
PI3K inhibitor (p110-α specific)

Chemical name

(S)-N1-(2-tert-butyl-4"-methyl-4,5"-bithiazol-2"-yl)pyrrolidine-1,2-dicarboxamide

Parent CAS No.

[1166227-08-2]

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