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axonmedchem/A 922500/5 mg/Axon 2059

A 922500

Based on 15 reference(s) in Google Scholar81015

Axon 2059

CAS [959122-11-3]

MF C26H24N2O4MW 428.48

  • Purity:98%
  • Optical purity:97% d.e.
  • Soluble in DMSO

A 922500

Description

Highly potent and selective diacylglycerol acyltransferase (DGAT) isomer 1 (DGAT-1) inhibitor with nanomolar potency
G Zhao et al. Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor. J. Med. Chem. 2008, 51(3), 380-383.
AJ King et al. Diacylglycerol Acyltransferase 1 Inhibition Lowers Serum Triglycerides in the Zucker Fatty Rat and the Hyperlipidemic Hamster. J. Pharmacol. Exp. Ther.2009, 330(2), 526-531.
AJ King et al. In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia. Eur. J. Pharmacol. 2010, 637(1-3), 155-161.
  • Certificate of Analysis
  • Material Safety Data Sheet
Cell Signaling & OncologyDiabetes & MetabolismDGAT-1EC 2.3.1.20
Highly potent and selective diacylglycerol acyltransferase 1 (DGAT-1) inhibitor

Chemical name

(1R,2R)-2-(4"-(3-phenylureido)biphenylcarbonyl)cyclopentanecarboxylic acid

Parent CAS No.

[959122-11-3]

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