Deprecated: Required parameter $cat_id follows optional parameter $type in /www/wwwroot/ebimall.com/systems/hong.php on line 2088

Deprecated: Required parameter $where follows optional parameter $tree_id in /www/wwwroot/ebimall.com/systems/hlb.php on line 3505
axonmedchem/A 769662/5 mg/Axon 1466188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
您好,欢迎您进入188进口试剂采购网网站! 服务热线:4000-520-616
蚂蚁淘商城 | 现货促销 | 科研狗 | 生物在线
产品资料

axonmedchem/A 769662/5 mg/Axon 1466

A 769662

Based on 12 reference(s) in Google Scholar91012

Axon 1466

CAS [844499-71-4]

MF C20H12N2O3SMW 360.39

  • Purity:99%
  • Soluble in DMSO

A 769662

Description

Potent and selective activator of AMP-activated protein kinase (AMPK) β1 subunit-containing complexes
B Cool et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metabolism. 2006, 3, 403.
M Sanders et al. Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J. Biol. Chem. 2007, 282, 32539.
O Göransson et al. Mechanism of Action of A-769662, a Valuable Tool for Activation of AMP-activated Protein Kinase. J. Biol. Chem. 2007, 282, 32549-32560.
JW Scott et al. Thienopyridone drugs are selective activators of AMP-activated protein kinase β1-containing complexes. Chem. Biol. 2008, 15, 1220.
JT Treebak et al. A-769662 activates AMPK β1-containing complexes but induces glucose uptake through a PI3 kinase-dependent pathway in mouse skeletal muscle. Am. J. Physiol. Cell Physiol. 2009, 297(4), C1041-C1052.
  • Certificate of Analysis
  • Material Safety Data Sheet
Cell Signaling & OncologyDiabetes & MetabolismStem CellAMPKPI3K-Akt-mTOREC 2.7.11.31
AMPK activator

Chemical name

6,7-Dihydro-4-hydroxy-3-(2"-hydroxy[1,1"-biphenyl]-4-yl )-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile

Parent CAS No.

[844499-71-4]

新闻动态
行业前沿
技术文章
最新产品