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axonmedchem/A-196/10 mg/Axon 2705

A-196

Based on 1 reference(s) in Google Scholar8101

Axon 2705

CAS [1982372-88-2]

MF C18H16Cl2N4MW 359.25

  • Purity:99%
  • Soluble in 0.1N HCl(aq) and DMSO

A-196

Description

A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 ((IC50 values of 25 and 144 nM, respectively). In cells, A-196 induced a global decrease in H4K20me2 and H4K20me3 and a concomitant increase in H4K20me1. A-196 inhibited 53BP1 foci formation upon ionizing radiation and reduced NHEJ-mediated DNA-break repair but did not affect homology-directed repair.

KEYWORDS: A-196 | supplier | SUV4-20 inhibitor | A196 | A 196 | CAS [1982372-88-2] | Non Selective (Lysine Sites Proteins) | PKMT | Inhibitor | Enzymes | Protein Lysine Methyltransferase | Histone Methyltransferase | SUV420H1 | SUV420H2

  • References
  • Certificates
  • Categories
  • Extra info
KD Bromberg et al. The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nat Chem Biol. 2017 Mar;13(3):317-324.
  • Certificate of Analysis
  • Material Safety Data Sheet
Cell Signaling & OncologyEpigeneticsEC 2.1.1.43PKMT
Potent and selective inhibitor of SUV4-20

Chemical name

6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine

Parent CAS No.

[1982372-88-2]

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