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axonmedchem/Abiraterone - CB 7598/10 mg/Axon 1873

Abiraterone - CB 7598

Based on 12 reference(s) in Google Scholar91012

Axon 1873

CAS [154229-19-3]

MF C24H31NOMW 349.51

  • Purity:100%
  • Optical purity:Optically pure
  • Moderately soluble in DMSO

Abiraterone

Description

Inhibitor of the steroidal enzyme 17 α-hydroxylase/C17,20 lyase (CYP17A1); a drug used in castration-resistant prostate cancer (CRPC); active component of its formulated prodrug abiraterone acetate (Axon 1874), which is also available

  • References
  • Certificates
  • Categories
  • Extra info
G Attard et al. Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer. BJU Int. 2005, 96 (9), 1241–1246.
JE Ang et al. CYP17 blockade by abiraterone: further evidence for frequent continued hormone-dependence in castration-resistant prostate cancer. Br. J. Cancer 2009, 100(5), 671–675.
  • Certificate of Analysis
  • Material Safety Data Sheet
Cell Signaling & OncologyDiabetes & MetabolismEndocrinologyEC 1.14.99.9Cytochrome P450
Inhibitor of CYP17A1

Chemical name

(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

Parent CAS No.

[154229-19-3]

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