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| Description | |
|---|---|
| CatalogueNumber | MAB5280X |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-TyrosineHydroxylaseAntibody,clone2/40/15,AlexaFluor®488 |
| ProductInformation | |
|---|---|
| Format | AlexaFluor®488 |
| Presentation | PurifiedimmunoglobulinconjugatedtoAlexaFluor®488.LiquidinPhosphatebufferwith15mg/mLBSAasastABIlizerand0.1%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat2-8°Cinundilutedaliquotsinthedarkforupto6monthsafterdateofreceipt. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Purifiedtyrosinehydroxylase(EC1.14.16.2)fromaratpheochromocytoma(2). |
| Clone | clone2/40/15 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | Tyrosinehydroxylase(TH)catalyzestherate-determininginitialstepinthebiosynthesisofcatecholaminessuchasdopamine,noradrenalineandadrenaline.Thereforetheantibodyisusedtostaindopaminergeousandadrenergeousneuronsaswellasthechromaffinetissueoftheadrenalmedulla.CelllinessuchasthePC12line,whichisderivedfromaratpheochromocytomaalso,showpositivereactions.Inimmunoblotsofadrenalmedullatissue,theantibodyrecognizesasingleproteinbandinthemolecularweightrangeof56-60kD. |
| Isotype | IgG2a |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Tyrosinehydroxylaseisinvolvedintheconversionoftyrosinetodopamine.Astherate-limitingenzymeinthesynthesisofcatecholamines,tyrosinehydroxylasehasakeyroleinthephysiologyofadrenergicneurons. |
| GeneSymbol |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P07101#Playsanimportantroleinthephysiologyofadrenergicneurons. COFACTOR:Fe(2+)ion. SIZE:528aminoacids;58524Da TISSUESPECIFICITY:Mainlyexpressedinthebrainandadrenalglands. DISEASE:SwissProt:P07101#DefectsinTHarethecauseofautosomalrecessiveSegawasyndrome[MIM:605407];alsoknownasDOPA-responsivedystonia.Typically,itbeginsinchildhoodoradolescencewithprogressivedifficultyinwalkingand,insomecases,spasticity.Somecasespresentwithparkinsoniansymptomsininfancyandarereferredtoasautosomalrecessiveinfantileparkinsonism. SIMILARITY:SwissProt:P07101##Belongstothebiopterin-dependentaromaticaminoacidhydroxylasefamily. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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