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| Description | |
|---|---|
| CatalogueNumber | 05-755 |
| BrandFamily | Upstate |
| TradeName |
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| Description | Anti-MEL-CAM(MUC18Antibody,CD146),cloneA32 |
| Overview | MEL-CAMisalsoknownasMUC18,CD146,S-Endo-1,orA32melanoma-associatedantigen |
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | 0.1MTris-glycine,pH7.4,0.15MNaCl,0.05%sodiumazidebeforetheadditionofglycerolto30% |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | 2yearsat-20°C |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | humanprimaryWM902Bmelanomacells |
| Clone | A32 |
| Host | Mouse |
| Specificity | MEL-CAM |
| Isotype | IgG1κ |
| SpeciesReactivity |
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| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
|
| PurificationMethod | ProteinGPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P43121#Playsaroleincelladhesion,andincohesionoftheendothelialmonolayeratintercellularjunctionsinvasculartissue.Itsexpressionmayallowmelanomacellstointeractwithcellularelementsofthevascularsystem,therebyenhancinghematogeneoustumorspread.Couldbeanadhesionmoleculeactiveinneuralcrestcellsduringembryonicdevelopment.ActsassurfacereceptorthattriggerstyrosinephosphorylationofFYNandPTK2,andatransientincreaseintheintracellularcalciumconcentration. SIZE:646aminoacids;71607Da SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Detectedinendothelialcellsinvasculartissuethroughoutthebody.Mayappearatthesurfaceofneuralcrestcellsduringtheirembryonicmigration.Appearstobelimitedtovascularsmoothmuscleinnormaladulttissues.Associatedwithtumorprogressionandthedevelopmentofmetastasisinhumanmalignantmelanoma.ExpressedmoststronglyonmetastaticlesionsandadvancedprimarytumorsandisonlyrarelydetectedinbenignmelanocyticneviandthinprimarymelanomaswithalowprobABIlityofmetastasis. SIMILARITY:SwissProt:P43121##Contains3Ig-likeC2-type(immunoglobulin-like)domains.&Contains2Ig-likeV-type(immunoglobulin-like)domains. |
| MolecularWeight | ~113kDa |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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