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Millipore/05-755 | Anti-MEL-CAM (MUC18 Antibody, CD146), clone A32/05-755/200 µg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Millipore/05-755 | Anti-MEL-CAM (MUC18 Antibody, CD146), clone A32/05-755/200 µg

Description
CatalogueNumber05-755
BrandFamilyUpstate
TradeName
  • Upstate
DescriptionAnti-MEL-CAM(MUC18Antibody,CD146),cloneA32
OverviewMEL-CAMisalsoknownasMUC18,CD146,S-Endo-1,orA32melanoma-associatedantigen
ProductInformation
FormatPurified
Presentation0.1MTris-glycine,pH7.4,0.15MNaCl,0.05%sodiumazidebeforetheadditionofglycerolto30%
StorageandShippingInformation
StorageConditions2yearsat-20°C
Applications
ApplicationThisAnti-MEL-CAM(MUC18Antibody,CD146),cloneA32isvalidatedforuseinIP,WB,IC,IHforthedetectionofMEL-CAM(MUC18.
KeyApplications
  • Immunoprecipitation
  • WesternBlotting
  • Immunocytochemistry
  • Immunohistochemistry
BIOLOGicalInformation
ImmunogenhumanprimaryWM902Bmelanomacells
CloneA32
HostMouse
SpecificityMEL-CAM
IsotypeIgG1κ
SpeciesReactivity
  • HumanOnly
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
GeneSymbol
  • MCAM
  • MUC18
  • Gicerin
  • CD146
PurificationMethodProteinGPurified
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P43121#Playsaroleincelladhesion,andincohesionoftheendothelialmonolayeratintercellularjunctionsinvasculartissue.Itsexpressionmayallowmelanomacellstointeractwithcellularelementsofthevascularsystem,therebyenhancinghematogeneoustumorspread.Couldbeanadhesionmoleculeactiveinneuralcrestcellsduringembryonicdevelopment.ActsassurfacereceptorthattriggerstyrosinephosphorylationofFYNandPTK2,andatransientincreaseintheintracellularcalciumconcentration.
SIZE:646aminoacids;71607Da
SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
TISSUESPECIFICITY:Detectedinendothelialcellsinvasculartissuethroughoutthebody.Mayappearatthesurfaceofneuralcrestcellsduringtheirembryonicmigration.Appearstobelimitedtovascularsmoothmuscleinnormaladulttissues.Associatedwithtumorprogressionandthedevelopmentofmetastasisinhumanmalignantmelanoma.ExpressedmoststronglyonmetastaticlesionsandadvancedprimarytumorsandisonlyrarelydetectedinbenignmelanocyticneviandthinprimarymelanomaswithalowprobABIlityofmetastasis.
SIMILARITY:SwissProt:P43121##Contains3Ig-likeC2-type(immunoglobulin-like)domains.&Contains2Ig-likeV-type(immunoglobulin-like)domains.
MolecularWeight~113kDa
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
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