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| Description | |
|---|---|
| CatalogueNumber | AB15467 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-ARG3.1Antibody |
| AlternateNames |
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| BackgroundInformation | Arc/Arg3.1isanimmediate-earlygenewhosemRNAisrapidlytranscribedandtargetedtodendritesofneuronsastheyengageininformationprocessingandstorage.Arc/Arg3.1isknowntoberequiredfordurableformsofsynapticplasticityandlearning.Arc/Arg3.1hasbeenshowntobeexpressedinneuronalcellbodiesanddendritesinthebrainregionsincludingstriatumandcortexhippocampus. |
| ProductInformation | |
|---|---|
| Format | Serum |
| Presentation | Lyophilized.Reconstitutewith50μLofsteriledistilledwater.Centrifugetoremoveanyinsolublematerial.Containsnopreservative. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainlyophilizedmaterialfrozenat-20°Cto-70°Cforupto12monthsafterdateofreceipt.Afterreconstitutionmaintainat-20°Cinundilutedaliquotsforupto6months.Avoidrepeatedfreeze/thawcycles.Glycerol(1:1,ACSorbettergrade)canbeaddedforadditionalstABIlity. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptidecorrespondingtoaregionwithintheC-terminusofhumanARG3.1protein. |
| Host | Rabbit |
| Specificity | ARG3.1[GrowthfactorARC,Activityregulatedcytoskeleton] |
| SpeciesReactivity |
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| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
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| PurificationMethod | Serum |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q7LC44#Requiredforconsolidationofsynapticplasticityaswellasformationoflong-termmemory.RegulatesendocytosisofAMPAreceptorsinresponsetosynapticactivity.RequiredforhomeostaticsynapticscalingofAMPAreceptors(Bysimilarity). SIZE:396aminoacids;45316Da SUBUNIT:InteractswithSH3GL1/endophilin-2,SH3GL3/endophilin-3andDNM2/DYN2(Bysimilarity). SUBCELLULARLOCATION:Cytoplasm,cytoskeleton(Bysimilarity).Endosome(Bysimilarity).Acrosome(Bysimilarity).Celljunction,synapse,postsynapticcellmembrane,postsynapticdensity(Bysimilarity).Cellprojection,dendrite(Bysimilarity).Cellprojection,dendriticspine(Bysimilarity).Celljunction,synapse(Bysimilarity).Note=Associatedwiththecellcortexofneuronalsomaanddendrites.Enrichedinpostsynapticdensityofdendriticspines.Associatedwiththespermtail(Bysimilarity). SIMILARITY:SwissProt:Q7LC44##BelongstotheARC/ARG3.1family. |
| PhysicochemicalInformation |
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