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| Description | |
|---|---|
| CatalogueNumber | AB5852 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-SHANK1aAntibody,NT |
| BackgroundInformation | Shankisanovelfamilyofpostsynapticdensityproteins(PSD)thatbindtoPDS-95-associatedproteinGKAP.ItsputativefunctionistoactasascaffoldproteininthePSDtocross-linkNMDAreceptors/PSD-95complexesandcouplethemtoregulatorsoftheactinCytoskeleton.Shank1aisasplicevariantofShank1. |
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | Purifiedimmunoglobulin.LiquidinPBScontaining0.02%sodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cinundilutedaliquotsforupto12monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptidecorrespondingtotheN-terminusofratShank1a. |
| Epitope | N-terminus |
| Host | Rabbit |
| Specificity | RecognizesShank1a,N-terminal. |
| SpeciesReactivity |
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| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q9Y566#Seemstobeanadapterproteininthepostsynapticdensity(PSD)ofexcitatorysynapsesthatinterconnectsreceptorsofthepostsynapticmembraneincludingNMDA-typeandmetabotropicglutamatereceptorsviacomplexeswithGKAP/PSD-95andHomer,respectively,andtheactin-basedcytoskeleton.Mayplayaroleinthestructuralandfunctionalorganizationofthedendriticspineandsynapticjunction. SIZE:2161aminoacids;225021Da SUBUNIT:MayhomomultimerizeviaitsSAMdomain(Bysimilarity).InteractswiththeC-terminusofSSTR2viathePDZdomain.InteractswithIGSF9,SHARPIN,SPTAN1,HOMER1andDLGAP1/GKAPisoforms1and2(Bysimilarity).PartofacomplexwithDLG4/PSD-95andDLGAP1/GKAP(Bysimilarity).InteractswithBAIAP2. SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Celljunction,synapse,postsynapticcellmembrane,postsynapticdensity(Bysimilarity).Celljunction,synapse(Bysimilarity).Note=Postsynapticdensityofneuronalcells(Bysimilarity).TISSUESPECIFICITY:Expressedinbrainparticularlyintheamygdala,hippocampus,substantianigraandthalamus.Isoform2seemstobeexpressedubiquitously. SIMILARITY:SwissProt:Q9Y566##BelongstotheSHANKfamily.&Contains6ANKrepeats.&Contains1PDZ(DHR)domain.&Contains1SAM(sterilealphamotif)domain.&Contains1SH3domain. |
| PhysicochemicalInformation |
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