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| Description | |
|---|---|
| CatalogueNumber | MAB5620 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-NorepinephrineTransporterAntibody |
| AlternateNames |
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| ProductInformation | |
|---|---|
| Format | Ascites |
| Presentation | Mouseascites.Liquid.Containsnopreservative. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cinundilutedaliquotsforupto6monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles. |
| Applications | |
|---|---|
| Application | DetectNorepinephrineTransporterusingthisAnti-NorepinephrineTransporterAntibodyvalidatedforuseinIH. |
| KeyApplications |
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| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptidefromhumannorepinephrineTransporter. |
| Host | Mouse |
| Specificity | NorepinephrineTransporter,humanandnon-humanprimate. |
| Isotype | IgG |
| SpeciesReactivity |
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | TheSLC6A2geneencodesanorepinephrine(noradrenaline)transporter,whichisresponsIBLeforreuptakeofnorepinephrineintopresynapticnerveterminalsandisaregulatorofnorepinephrinehomeostasis(Kimetal.,2006[PubMed17146058]).[suppliedbyOMIM] |
| GeneSymbol |
|
| PurificationMethod | Ascites |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P23975#Aminetransporter.Terminatestheactionofnoradrenalinebyitshighaffinitysodium-dependentreuptakeintopresynapticterminals. SIZE:617aminoacids;69332Da SUBUNIT:InteractswithPRKCABP. SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. DISEASE:SwissProt:P23975#DefectsinSLC6A2areacauseoforthostaticintolerance(OI)[MIM:604715].OIisasyndromecharacterizedbylightheadedness,fatigue,alteredmentationandsyncope.Itisassociatedwithposturaltachycardia.Plasmanorepinephrineconcentrationisabnormallyhigh. SIMILARITY:SwissProt:P23975##Belongstothesodium:neurotransmittersymporter(SNF)family. MISCELLANEOUS:Thisproteinisthetargetofpsychomotorstimulantssuchasamphetaminesorcocaine. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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