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Millipore/MAB1567 | Anti-Myelin Associated Glycoprotein Antibody, clone 513/MAB1567/100 µg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Millipore/MAB1567 | Anti-Myelin Associated Glycoprotein Antibody, clone 513/MAB1567/100 µg

Description
CatalogueNumberMAB1567
BrandFamilyChemicon®
TradeName
  • Chemicon
DescriptionAnti-MyelinAssociatedGlycoproteinAntibody,clone513
AlternateNames
  • MAG
BackgroundInformationMyelin-associatedglycoprotein(MAG),amemberoftheimmunoglobulinsuperfamily,isamembraneglycoproteinof100kDa,andisthoughttobeinvolvedintheprocessofmyelination.Axonalregenerationintheadultcentralnervoussystem(CNS)islimitedbytwoproteinsinmyelin,NogoandMAG.MAGhasbeenimplicatedintheinhibitionofnerveregenerationintheCNS.
ProductInformation
FormatPurified
Control
  • Rathippocampustissue,ratbrainlysate,PC12cells.
PresentationPurifiedmousemonoclonalIgG1inbuffercontaining10mMpotassiumphosphatebuffer,50mMNaCl,pH7.5.Containsnopreservative.
StorageandShippingInformation
StorageConditionsStablefor1yearat-20ºCfromdateofreceipt.
Applications
ApplicationDetectMyelinAssociatedGlycoproteinusingthisAnti-MyelinAssociatedGlycoproteinAntibody,clone513validatedforuseinIC,IH&WB.
KeyApplications
  • Immunocytochemistry
  • Immunohistochemistry
  • WesternBlotting
ApplicationNotesWesternBlot:
20μg/mLofapreviouslotwasusedonwesternblotundernon-reducingconditionsonly.{SeeEllezam,2003}

Immunocytochemistry:
5-10µg/mLofapreviouslotwasused,methanolfixationrequired.

Optimalworkingdilutionsmustbedeterminedbyenduser.
BIOLOGicalInformation
ImmunogenL2epitopecarryingglycoproteinextractof1-2dayoldchickenbrain.
Clone513
ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
HostMouse
SpecificityDetectsMyelinAssociatedGlycoprotein(MAG)inimmunohistochemistryonfrozensections,immunocytochemistryandWesternblot(undernon-reducingconditions).MAB1567isusefulformyelinogenesisandmultiplesclerosisstudies.
IsotypeIgG1
SpeciesReactivity
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Rat
  • Frog
AntibodyTypeMonoclonalAntibody
EntrezGeneNumber
EntrezGeneSummaryTheproteinencodedbythisgeneisatypeImembraneproteinandmemberoftheimmunoglobulinsuperfamily.Itisthoughttobeinvolvedintheprocessofmyelination.Itisalectinthatbindstosialylatedglycoconjugatesandmediatescertainmyelin-neuroncell-cellinteractions.Twoalternativelysplicedtranscriptsencodingdifferentisoformshavebeendescribedforthisgene.
GeneSymbol
  • MAG
  • SIGLEC4A
  • SIGLEC-4A
  • Siglec-4a
  • S-MAG
  • GMA
PurificationMethodProteinAPurfied
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P20916#Adhesionmoleculeinpostnatalneuraldevelopmentthatmediatessialic-aciddependentcell-cellinteractionsbetweenneuronalandmyelinatingcells.Preferentiallybindstoalpha2,3-linkedsialicacid(Bysimilarity).
SIZE:626aminoacids;69069Da
SUBUNIT:BindstoRTN4R(Bysimilarity).
SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
SIMILARITY:SwissProt:P20916##Belongstotheimmunoglobulinsuperfamily.SIGLEC(sialicacidbindingIg-likelectin)family.&Contains4Ig-likeC2-type(immunoglobulin-like)domains.&Contains1Ig-likeV-type(immunoglobulin-like)domain.
MolecularWeight100kDa
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
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