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PhosphoSolutions/p62 (Thr269 Ser272) Antibody/p196-269/100 µl188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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PhosphoSolutions/p62 (Thr269 Ser272) Antibody/p196-269/100 µl

Rabbitpolyclonalantibody

PooledSerum
Size:
100µl
Formulation:
AffinityPurifiedfromPooledSerum
Specificity:
Human,Non-humanprimate
Applications:
WB1:1,000
Species:
Rabbit
MolecularReference:
~62kDa
CiteThisAntibody:
PhosphoSolutionsCat#p196-269,RRID:AB_2492198
Antigen/Purification:ExpandCollapse

Theantigenisaphosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Thr269/Ser272ofhumanp62.

Theantibodyispreparedfrompooledrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.

BIOLOGicalSignificance:ExpandCollapse

Theproteinscaffoldandsignalingregulatorp62(alsoknownassequestosome1(SQSTM1))isimportantincriticalcellularfunctions,includingbonehomeostasis,obesity,andcancer,becauseofitsinteractionswithvarioussignalingintermediaries.p62isoverexpressedinmanyhumancancersandisinducedduringcelltransformation.cdk1phosphorylatesp62invitroandinvivoatThr<sup>269</sup>andSer<sup>272</sup>,whichisnecessaryforthemaintenanceofappropriatecyclinB1levelsandthelevelsofcdk1activitynecessarytoallowcellstoproperlyenterandexitmitosis(Moscatetal.,2011).Thelackofcdk1-mediatedphosphorylationofp62leadstoafasterexitfrommitosis,translatingintoenhancedcellproliferationandtumOrigenesisinresponsetoRas-inducedtransformation(Moscatetal.,2011).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgBSApermland50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

MoscatJ,LinaresJF,AmanchyR,Diaz-MecoMT(2011)Phosphorylationofp62bycdk1ControlstheTimelyTransitofCellsthroughMitosisandTumorCellProliferation.MolCellBiol.1:105-17.

PankivS,LamarkT,BruunJA,ØvervatnA,BjørkøyG,andJohansen(2010).NucleocytoplasmicShuttlingofp62/SQSTM1andItsRoleinRecruitmentofNuclearPolyubiquitinatedProteinstoPromyelocyticLeukemiaBodies.JBiolChem.8:5941-53

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