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PhosphoSolutions/Syntaxin 1A Antibody/1990-STX/100 µl188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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PhosphoSolutions/Syntaxin 1A Antibody/1990-STX/100 µl

Mousemonoclonalantibody

Size:
100µl
Formulation:
ProteinGPurified
Specificity:
Rat,Human,Porcine
Applications:
WB1:1,000IHC1:100
Species:
Mouse
MolecularReference:
~36kDa
CiteThisAntibody:
PhosphoSolutionsCat#1990-STX,RRID:AB_2492254
Antigen/Purification:ExpandCollapse

Theantigenisasynapticimmunoprecipitate(crude)fromhumanbrain.

TheantibodyisProteinGpurifiedculturesupernatant.

BIOLOGicalSignificance:ExpandCollapse

Syntaxinsareafamilyofproteinsinvolvedinthedockingofsynapticvesicleswiththeplasmamembrane.Syntaxin,alongwithsynaptobrevinandSNAP-25,formstheSNAREcomplexwhichmediatessynapticvesiclefusionandexocytosis.BindingofMunc18-1totheN-terminusofsyntaxin1hasbeendemonstratedtobeessentialforexocyticmembranefusion(Khvotchevetal.,2007).Decreasedlevelsofphosphorylatedsyntaxin1intheprefrontalcortexhaverecentlybeencorrelatedwithschizophrenia(Castilloetal.,2010).

Storage

100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.

Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.

GeneralReferences

KhvotchevM,DulubovaI,SunJ,DaiH,RizoJ,SüdhofTC(2007)DualmodesofMunc18-1/SNAREinteractionsarecoupledbyfunctionallycriticalbindingtosyntaxin-1Nterminus.JNeurosci.2007Nov7;27(45):12147-55

CastilloMA,GhoseS,TammingaCA,Ulery-ReynoldsPG(2010)Deficitsinsyntaxin1phosphorylationinschizophreniaprefrontalcortex.BiolPsychiatry.67(3):208-16

Honer,W.G.,Hu,L.&Davies,P.Humansynapticproteinswithaheterogeneousdistributionincerebellumandvisualcortex.BrainResearch609,9-20(1993).

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