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Xencor/XmAb5871/XmAb5871/1 Ea

CompletedaPhase1b/2aclinicaltrialforthetreatmentofmoderate-to-severerheumatoidarthritis;enteredintoPhase2developmentforthetreatmentofIgG4-RelatedDisease,andalsoforthetreatmentofSystemicLupusErythematosus.XmAb5871isafirst-in-classmonoclonalantibodythattargetsCD19withitsvariabledomainandusestheXmAbimmuneinhibitoryFcdomaintotargetFcγRIIb,areceptorthatinhibitsBcellfunction.XmAb5871isthefirstdrugcandidatetoourknowledgethattargetsFcγRIIbinhibition.WehavedemonstratedinanimalmodelsandhumanclinicaltrialsthatXmAb5871inhibitsB-cellfunctionwithoutdestroyingtheseimportantimmunecells,enablingthenaturalimmunesystemtofunctiononcetreatmentisnolongerneeded.B-cellinhibitionisaprovenstrategyformanyautoimmunediseases,fromrheumatoidarthritisandlupustorareconditionssuchasIgG4-relateddisease.XmAb5871’shighlypotentandbroadblockadeofB-cellactivationwithoutdepletingBcellsdifferentiatesitfromotherB-celltargetingtherapiesandhaspotentialfortreatingmanyautoimmunediseases.
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