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Xencor/XmAb13676/XmAb13676/1 Ea

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XmAb13676

EnteredPhase1clinicaltrialinnon-Hodgkinlymphomain2017.

XmAb13676isatumor-targetedantibodythatcontainsbothaCD20bindingdomainandacytotoxicT-cellbindingdomain(CD3).AnXmAbBispecificFcdomainservesasthescaffoldforthesetwoantigenbindingdomainsandconferslongcirculatinghalf-life,stABIlityandeaseofmanufactureonXmAb13676.CD20ishighlyexpressedonB-celltumorcells,includingchroniclymphocyticleukemia(CLL)andnon-Hodgkinlymphoma(NHL)cells.EngagementofCD3byXmAb13676activatesTcellsforhighlypotentandtargetedkillingofCD20-expressingtumorcells.

ThestructuralstabilityandmodularityenabledbytheXmAbBispecificFcdomainallowedthetuningofXmAb13676’spotencytobalanceanti-tumoractivitywiththereductionofimmunetoxicitythatcanresultfromT-cellactivation.

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